In this case, it was 'Rio.' The high-flying kids' movie, which features the voice talent of Anne Hathaway, Jesse Eisenberg and more, pulled in an estimated $40 million, making it the year's best opening thus far.

Coming in at a distant second was the much-anticipated 'Scream 4,' which opened with an underwhelming $19.3 million. That number is especially disappointing, considering 'Scream 3' grossed $34.7 million in its opening weekend 11 years ago.

The 65-year-old Oscar winner certainly gave it her all in an episode that seemed to rely on two things: her never-aging beauty and her ability to impersonate famous people.

When she wasn't pole dancing or letting Kristen Wiig get up close and personal with her, uh, "magical bosom," Mirren gamely impersonated everyone from actress Helena Bonham Carter to author Mary Shelley. In one sketch, Mirren portrayed First Lady Eleanor Roosevelt, who, in a riff on the much-maligned miniseries 'The Kennedys,' was revealed to be a lesbian with a thing for Marilyn Monroe (Abby Elliot). The result? Some girl-on-girl action between Mirren and Elliot. (No complaints here.)

The good news: Brand's live-action/animated comedy 'Hop' took the top spot for the second weekend in a row, with $21.7 million. That marks a 42 percent drop from last weekend, bringing the film's grand total to $68.2 million thus far.

Unfortunately, Brand's other movie, 'Arthur,' a remake of the Oscar-winning '80s comedy starring Dudley Moore, underperformed with audiences, bringing in just $12.6 million. The movie, which also stars Greta Gerwig, Jennifer Garner and Helen Mirren, suffered from poor reviews that likely killed its word of mouth.